Endocrine Abstracts

Growth hormone (GH) secreted by the anterior pituitary gland regulates skeletal growth, metabolism and body composition. Although several of these actions are mediated by production of hepatic and local tissue IGF1, GH also acts independent of IGF1. GH is mainly produced from the pituitary as a systemic endocrine hormone, yet is also expressed in local tissues acting in an autocrine/paracrine/intracrine manner. Locally produced non-pituitary GH (npGH) signals the GHR to induce...